The same applies for people who unsubscribe via replies. They never get removed from the list and it often results in them clicking the SPAM button or negative brand impression when they continue to receive messages.

Also, many users reply to emails rather than clicking (despite many companies indicating a do-not-reply address – not the most customer service friendly way of inviting customer communication, as we know!) Companies wishing to engage with customers invite them to reply as it is a natural 2-way communication method and eliminates the need for clients to click to other places, fill out often lengthy contact forms etc.